Closing the gap between 19F and 18F chemistry
Positron emission tomography (PET) has become an invaluable tool for drug discovery and
diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET …
diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET …
Current status and progress in using radiolabelled PARP-1 inhibitors for imaging PARP-1 expression in tumours
Q Wang, J Zhang - European Journal of Medicinal Chemistry, 2022 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in the DNA repair
process, and the overexpression of PARP-1 in several tumours makes this enzyme a …
process, and the overexpression of PARP-1 in several tumours makes this enzyme a …
Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration
Positron emission tomography is a widely used imaging platform for studying physiological
processes. Despite the proliferation of modern synthetic methodologies for radiolabeling, the …
processes. Despite the proliferation of modern synthetic methodologies for radiolabeling, the …
Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction
A Craig, J Kogler, M Laube, M Ullrich, CK Donat… - Pharmaceutics, 2023 - mdpi.com
Early detection and treatment of cancers can significantly increase patient prognosis and
enhance the quality of life of affected patients. The emerging significance of the tumor …
enhance the quality of life of affected patients. The emerging significance of the tumor …
Recent Progress on Radiofluorination using Metals: Strategies for Generation of C-18 F Bonds
C–F bond formation is an important research topic in organic synthesis because of the wide
use of organofluorine compounds in various areas including pharmaceuticals, agricultural …
use of organofluorine compounds in various areas including pharmaceuticals, agricultural …
DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer
Given the clinical potential of poly (ADP-ribose) polymerases (PARP) imaging for the
detection and stratification of various cancers, the development of novel PARP imaging …
detection and stratification of various cancers, the development of novel PARP imaging …
Next Generation Copper Mediators for the Efficient Production of 18F‐Labeled Aromatics
C Hoffmann, N Kolks, D Smets… - … A European Journal, 2023 - Wiley Online Library
Cu‐mediated radiofluorination is a versatile tool for the preparation of 18F‐labeled (hetero)
aromatics. In this work, we systematically evaluated a series of complexes and identified …
aromatics. In this work, we systematically evaluated a series of complexes and identified …
[18F]pFBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain
Preclinical models of neurological diseases and gene therapy are essential for
neurobiological research. However, the evaluation of such models lacks reliable reporter …
neurobiological research. However, the evaluation of such models lacks reliable reporter …
Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma
TH Lai, B Wenzel, S Dukić-Stefanović… - European Journal of …, 2024 - Springer
Glioma are clinically challenging tumors due to their location and invasiveness nature,
which often hinder complete surgical resection. The evaluation of the isocitrate …
which often hinder complete surgical resection. The evaluation of the isocitrate …
DNA Repair Enzyme Poly (ADP-Ribose) Polymerase 1/2 (PARP1/2)-Targeted Nuclear Imaging and Radiotherapy
NT Nguyen, A Pacelli, M Nader, S Kossatz - Cancers, 2022 - mdpi.com
Simple Summary In parallel to the successful clinical implementation of PARP1/2 inhibitors
as anti-cancer drugs, which interfere with the DNA repair machinery, these small molecule …
as anti-cancer drugs, which interfere with the DNA repair machinery, these small molecule …