Infectious disease-associated encephalopathies

MC Barbosa-Silva, MN Lima, D Battaglini, C Robba… - Critical Care, 2021 - Springer
Infectious diseases may affect brain function and cause encephalopathy even when the
pathogen does not directly infect the central nervous system, known as infectious disease …

Current understanding of long-term cognitive impairment after sepsis

Y Li, M Ji, J Yang - Frontiers in immunology, 2022 - frontiersin.org
Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a
dysregulated host response to infection. Although the incidence and mortality of sepsis …

Simvastatin downregulates the SARS-CoV-2-induced inflammatory response and impairs viral infection through disruption of lipid rafts

L Teixeira, JR Temerozo, FS Pereira-Dutra… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …

A review and hypothesized model of the mechanisms that underpin the relationship between inflammation and cognition in the elderly

M Tangestani Fard, C Stough - Frontiers in aging neuroscience, 2019 - frontiersin.org
Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …

INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/PKA/CREB signaling …

P Jin, S Deng, M Tian, C Lenahan, P Wei, Y Wang… - Experimental …, 2021 - Elsevier
Background Survivors of sepsis must often endure significant cognitive and behavioral
impairments after discharge, but research on the relevant mechanisms and interventions …

Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities

EC van der Slikke, AY An, REW Hancock… - EBioMedicine, 2020 - thelancet.com
Sepsis is a major health problem worldwide. As the number of sepsis cases increases, so
does the number of sepsis survivors who suffer from" post-sepsis syndrome" after hospital …

Preoperative medication use and postoperative delirium: a systematic review

GM Kassie, TA Nguyen, LM Kalisch Ellett, NL Pratt… - BMC geriatrics, 2017 - Springer
Background Medications are frequently reported as both predisposing factors and inducers
of delirium. This review evaluated the available evidence and determined the magnitude of …

Neuroinflammation in sepsis: molecular pathways of microglia activation

CA Moraes, C Zaverucha-do-Valle, R Fleurance… - Pharmaceuticals, 2021 - mdpi.com
Frequently underestimated, encephalopathy or delirium are common neurological
manifestations associated with sepsis. Brain dysfunction occurs in up to 80% of cases and is …

Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a …

J Jiang, Y Zou, C Xie, M Yang, Q Tong, M Yuan… - Brain, Behavior, and …, 2023 - Elsevier
Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

Long-term cognitive outcomes after sepsis: a translational systematic review

T Barichello, P Sayana, VV Giridharan… - Molecular …, 2019 - Springer
Sepsis is systemic inflammatory response syndrome with a life-threatening organ
dysfunction that is caused by an unbalanced host immune response in an attempt to …