Helix formation and stability in membranes
MJ McKay, F Afrose, RE Koeppe II… - Biochimica et Biophysica …, 2018 - Elsevier
In this article we review current understanding of basic principles for the folding of
membrane proteins, focusing on the more abundant alpha-helical class. Membrane …
membrane proteins, focusing on the more abundant alpha-helical class. Membrane …
Regulation of gramicidin channel function solely by changes in lipid intrinsic curvature
AM Maer, R Rusinova, LL Providence… - Frontiers in …, 2022 - frontiersin.org
Membrane protein function is regulated by the lipid bilayer composition. In many cases the
changes in function correlate with changes in the lipid intrinsic curvature (c 0), and c 0 is …
changes in function correlate with changes in the lipid intrinsic curvature (c 0), and c 0 is …
Design of Chiral β‐Double Helices from γ‐Peptide Foldamers
Chirality is ubiquitous in nature, and homochirality is manifested in many biomolecules.
Although β‐double helices are rare in peptides and proteins, they consist of alternating L …
Although β‐double helices are rare in peptides and proteins, they consist of alternating L …
Membrane elastic deformations modulate gramicidin A transbilayer dimerization and lateral clustering
OV Kondrashov, TR Galimzyanov, KV Pavlov… - Biophysical journal, 2018 - cell.com
Gramicidin A (gA) is a short β-helical peptide known to form conducting channels in lipid
membranes because of transbilayer dimerization. The gA conducting dimer, being shorter …
membranes because of transbilayer dimerization. The gA conducting dimer, being shorter …
Spontaneous curvature generation by peptides in asymmetric bilayers
1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA,
USA, 2Department of Biochemistry and Biophysics, Washington University in St. Louis, St …
USA, 2Department of Biochemistry and Biophysics, Washington University in St. Louis, St …
Atomistic characterization of gramicidin channel formation
We investigated gramicidin A (gA) subunit dimerization in lipid bilayers using microsecond-
long replica-exchange umbrella sampling simulations, millisecond-long unbiased molecular …
long replica-exchange umbrella sampling simulations, millisecond-long unbiased molecular …
Membrane bending moduli of coexisting liquid phases containing transmembrane peptide
A number of highly curved membranes in vivo, such as epithelial cell microvilli, have the
relatively high sphingolipid content associated with" raft-like" composition. Given the much …
relatively high sphingolipid content associated with" raft-like" composition. Given the much …
Molecular mechanism for gramicidin dimerization and dissociation in bilayers of different thickness
Membrane protein functions can be altered by subtle changes in the host lipid bilayer
physical properties. Gramicidin channels have emerged as a powerful system for elucidating …
physical properties. Gramicidin channels have emerged as a powerful system for elucidating …
Quantitative characterization of protein–lipid interactions by free energy simulation between binary bilayers
S Park, MS Yeom, OS Andersen… - Journal of chemical …, 2019 - ACS Publications
Using a recently developed binary bilayer system (BBS) consisting of two patches of laterally
contacting bilayers, umbrella sampling molecular dynamics (MD) simulations were …
contacting bilayers, umbrella sampling molecular dynamics (MD) simulations were …
Curvature energetics determined by alchemical simulation on four topologically distinct lipid phases
The relative curvature energetics of two lipids are tested using thermodynamic integration
(TI) on four topologically distinct lipid phases. Simulations use TI to switch between choline …
(TI) on four topologically distinct lipid phases. Simulations use TI to switch between choline …