The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …

The ubiquitylation machinery regulates several fundamental biological processes from
protein homeostasis to a wide variety of cellular signaling pathways. As a consequence, its …

Abstract MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the
ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that …

The study of ever more complex biomolecular assemblies implicated in human health and
disease is facilitated by a suite of complementary biophysical methods. Pulse dipolar …

HIV type I (HIV-1) reverse transcriptase (RT) catalyzes the conversion of viral RNA into DNA,
initiating the chain of events leading to integration of proviral DNA into the host genome. RT …

Skeletal muscle wasting represents a common trait in many conditions, including aging,
cancer, heart failure, immobilization, and critical illness. Loss of muscle mass leads to …

Paramagnetic (open-shell) systems, including transition metal ions, radical intermediates
and defect centres, are often involved in catalytic transformations. Despite the prevalence of …

The emergence of systems biology in the post-genomic era has led to investigating
increasingly complex macromolecular assemblies, emphasising holistic approaches in …

The study of complex biomolecular assemblies implicated in human health and disease is
increasingly performed under native conditions. Pulse Dipolar Electron paramagnetic …

Pulse dipolar EPR is an appealing strategy for structural characterisation of complex
systems in solution that complements other biophysical techniques. Significantly, the …