The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Adipose tissue is necessary to harbor energy. To handle excess energy, adipose tissue
expands by increasing adipocyte size (hypertrophy) and number (hyperplasia). Here, we …

The carboxylic acid functional group can be an important constituent of a pharmacophore,
however, the presence of this moiety can also be responsible for significant drawbacks …

The adipose tissue is a central metabolic organ in the regulation of whole-body energy
homeostasis. The white adipose tissue functions as a key energy reservoir for other organs …

In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …

The objective of the present study was to develop a rat model that replicates the natural
history and metabolic characteristics of human type 2 diabetes and is also suitable for …

Peroxisome proliferator-activated receptors (PPARs) α and γ are key regulators of lipid
homeostasis and are activated by a structurally diverse group of compounds including fatty …

Insulin was discovered more than 75 years ago, but only recently have we begun to
understand the mechanisms by which insulin promotes the uptake of glucose into cells. This …

The peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor that has a
pivotal role in adipocyte differentiation and expression of adipocyte-specific genes 1, 3. The …