Understanding the relations between the formation, structure, dynamics and functionality of
complex synthetic materials is one of the great challenges in chemistry and nanotechnology …

Correlative microscopy, the integration of two or more microscopy techniques performed on
the same sample, produces results that emphasize the strengths of each technique while …

Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic
features such as a compact circular genome. Consequently, in mammals, mitochondrial …

INTRODUCTION Our textbook understanding of the nanoscale organization of the cell and
its relationship to the thousands of proteins that drive cellular metabolism comes largely from …

Cancers that appear pathologically similar often respond differently to the same drug
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …

Many biological questions require fluorescence microscopy with a resolution beyond the
diffraction limit of light. Super-resolution methods such as Structured Illumination Microscopy …

Sample fixation by vitrification is critical for the optimal structural preservation of
biomolecules and subsequent high-resolution imaging by cryo-correlative light and electron …

We have developed a system for producing a supramolecular scaffold that permeates the
entire Escherichia coli cytoplasm. This cytoscaffold is constructed from a three-component …

The frontiers of bioimaging are currently being pushed toward the integration and correlation
of several modalities to tackle biomedical research questions holistically and across multiple …

Developments in microscopy have been instrumental to progress in the life sciences, and
many new techniques have been introduced and led to new discoveries throughout the last …