Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

The human heart's failure to replace ischemia-damaged myocardium with regenerated
muscle contributes significantly to the worldwide morbidity and mortality associated with …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …

Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition
leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac …

Mancozeb (MZ), an antibacterial pesticide, has been linked to reproductive toxicity,
neurotoxicity, and endocrine disruption. However, whether MZ has cardiactoxicity is unclear …

Oxidative stress contributes to the pathogenesis of aging‐associated heart failure. Among
various signaling pathways mediating oxidative stress, the NAD+‐dependent protein …

Berberine (BBR) confers cardioprotective effect against myocardial ischemia reperfusion
injury (MI/RI). Activation of Notch1/Hairy and enhancer of split 1 (Hes1) signaling also …