The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Importance Major depressive disorder (MDD) has been linked to imbalanced
communication among large-scale brain networks, as reflected by abnormal resting-state …

Depression is associated with social risk factors, social impairments and poor social
functioning. This paper gives an overview of these social aspects using the NIMH Research …

Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

In the 40 years since Aaron Beck first proposed his cognitive model of depression, the
elements of this model—biased attention, biased processing, biased thoughts and …

In this Seminar we discuss developments from the past 5 years in the diagnosis,
neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and …

Childhood maltreatment is associated with significant, enduring risk of psychiatric disorder.
In this paper, we review how neurocognitive alterations after maltreatment might indirectly …

To better understand intrinsic brain connections in major depression, we used a
neuroimaging technique that measures resting state functional connectivity using functional …