[HTML][HTML] Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase
AM Alfayomy, R Ashry, AG Kansy, AC Sarnow… - European Journal of …, 2024 - Elsevier
The Ataxia telangiectasia and RAD3-related (ATR) kinase is a key regulator of DNA
replication stress responses and DNA-damage checkpoints. Several potent and selective …
replication stress responses and DNA-damage checkpoints. Several potent and selective …
Histone deacetylase inhibitors modulate hormesis in leukemic cells with mutant FMS-like tyrosine kinase-3
Y Zeyn, K Hausmann, M Halilovic, M Beyer, HS Ibrahim… - Leukemia, 2023 - nature.com
The FMS-like tyrosine kinase-3 (FLT3) is mutated in~ 30% of acute myeloid leukemia (AML)
patients. Common FLT3 mutations are internal tandem duplications (FLT3-ITD) and point …
patients. Common FLT3 mutations are internal tandem duplications (FLT3-ITD) and point …
[HTML][HTML] Cannabidiol protects against acute aortic dissection by inhibiting macrophage infiltration and PMAIP1-induced vascular smooth muscle cell apoptosis
Y Guo, Y Che, X Zhang, Z Ren, Y Chen, L Guo… - Journal of Molecular and …, 2024 - Elsevier
Acute aortic dissection (AAD) progresses rapidly and is associated with high mortality;
therefore, there remains an urgent need for pharmacological agents that can protect against …
therefore, there remains an urgent need for pharmacological agents that can protect against …