Chemistry and biology of ferritin

M Plays, S Müller, R Rodriguez - Metallomics, 2021 - academic.oup.com
Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

Ferritin, cellular iron storage and regulation

P Arosio, L Elia, M Poli - IUBMB life, 2017 - Wiley Online Library
Ferritin is considered the major iron storage protein which maintains a large iron core in its
cavity and has ferroxidase activity. There are many types of ferritin particularly in prokaryotes …

Genetically encoded multimeric tags for subcellular protein localization in cryo-EM

HKH Fung, Y Hayashi, VT Salo, A Babenko, I Zagoriy… - Nature …, 2023 - nature.com
Cryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of
macromolecular assemblies in their native cellular context. However, the localization of …

Mechanisms and regulations of ferroptosis

XD Zhang, ZY Liu, MS Wang, YX Guo… - Frontiers in …, 2023 - frontiersin.org
Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …

Bacterial iron detoxification at the molecular level

JM Bradley, DA Svistunenko, MT Wilson… - Journal of Biological …, 2020 - ASBMB
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

Large protein organelles form a new iron sequestration system with high storage capacity

TW Giessen, BJ Orlando, AA Verdegaal, MG Chambers… - Elife, 2019 - elifesciences.org
Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin
proteins are the major storage units for bioavailable forms of iron. Some organisms lack …

Widespread distribution of encapsulin nanocompartments reveals functional diversity

TW Giessen, PA Silver - Nature microbiology, 2017 - nature.com
Cells organize and regulate their metabolism via membrane-or protein-bound organelles. In
this way, incompatible processes can be spatially separated and controlled. In prokaryotes …

Encapsulins

TW Giessen - Annual review of biochemistry, 2022 - annualreviews.org
Subcellular compartmentalization is a defining feature of all cells. In prokaryotes,
compartmentalization is generally achieved via protein-based strategies. The two main …

Ferritin self-assembly, structure, function, and biotechnological applications

VV Sudarev, SM Dolotova, SM Bukhalovich… - International journal of …, 2023 - Elsevier
Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It
plays a crucial role in various metabolic pathways, inflammation processes, stress response …

Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae

JA Jones, MP Andreas, TW Giessen - Nature Communications, 2024 - nature.com
Encapsulins are self-assembling protein nanocompartments capable of selectively
encapsulating dedicated cargo proteins, including enzymes involved in iron storage, sulfur …