[HTML][HTML] WHF IASC roadmap on Chagas disease

LE Echeverría, R Marcus, G Novick, S Sosa-Estani… - Global …, 2020 - ncbi.nlm.nih.gov
Background: Chagas Disease is a neglected tropical disease caused by the protozoan
Trypanosoma cruzi, with some of the most serious manifestations affecting the …

Clinical and pharmacological profile of benznidazole for treatment of Chagas disease

J Müller Kratz, F Garcia Bournissen… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Chagas disease (CD) is one of the most neglected public health problems in
the Americas, where< 1% of the estimated 6 million people with the infection have been …

Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial

CA Morillo, H Waskin, S Sosa-Estani… - Journal of the American …, 2017 - jacc.org
Background: Benznidazole is recommended for treatment of Chagas infection. Effects of
combination therapy with benznidazole and posaconazole have not been tested in …

[HTML][HTML] Chagas disease research and development: Is there light at the end of the tunnel?

E Chatelain - Computational and structural biotechnology journal, 2017 - Elsevier
Chagas disease, or American trypanosomiasis, is the result of infection by the parasite
Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to …

Risk of chronic cardiomyopathy among patients with the acute phase or indeterminate form of Chagas disease: a systematic review and meta-analysis

S Chadalawada, S Sillau, S Archuleta… - JAMA network …, 2020 - jamanetwork.com
Importance Chagas cardiomyopathy is associated with substantial morbidity and mortality.
Precise estimates of the risk of developing cardiomyopathy among patients with the acute or …

Molecular diagnosis of Trypanosoma cruzi

AG Schijman - Acta tropica, 2018 - Elsevier
Chagas disease, caused by the kinetoplastid protozoan Trypanosoma cruzi, affects millions
of people, most of them neglected populations. The different phases of the disease, the …

[HTML][HTML] Benznidazole decreases the risk of chronic Chagas disease progression and cardiovascular events: A long-term follow up study

AM Hasslocher-Moreno, RM Saraiva… - …, 2021 - thelancet.com
Background Chagas disease (CD) remains an important endemic disease in Latin America.
However, CD became globalized in recent decades. The majority of the chronically infected …

Review of pharmacological options for the treatment of Chagas disease

F Lascano, F García Bournissen… - British journal of clinical …, 2022 - Wiley Online Library
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

[HTML][HTML] SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease–2023

JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
SciELO - Brazil - Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …

[HTML][HTML] Chagas disease: Historic perspective

C Chao, JL Leone, CA Vigliano - … et Biophysica Acta (BBA)-Molecular Basis …, 2020 - Elsevier
This review is a perspective on the history of Chagas disease, and it adopts a novel
approach from literary studies, historical documents and the science and epidemiology of …