Emerging roles of innate and adaptive immunity in Alzheimer's disease
X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …
The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
Y Shi, DM Holtzman - Nature Reviews Immunology, 2018 - nature.com
Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out
during the pathogenesis of the disease and in turn modulates disease progression. The …
during the pathogenesis of the disease and in turn modulates disease progression. The …
Neutrophils as protagonists and targets in chronic inflammation
O Soehnlein, S Steffens, A Hidalgo… - Nature Reviews …, 2017 - nature.com
Traditionally, neutrophils have been acknowledged to be the first immune cells that are
recruited to an inflamed tissue and have mainly been considered in the context of acute …
recruited to an inflamed tissue and have mainly been considered in the context of acute …
In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
[HTML][HTML] The blood-brain barrier in Alzheimer's disease
E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …
Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
E Zenaro, E Pietronigro, VD Bianca, G Piacentino… - Nature medicine, 2015 - nature.com
Inflammation is a pathological hallmark of Alzheimer's disease, and innate immune cells
have been shown to contribute to disease pathogenesis. In two transgenic models of …
have been shown to contribute to disease pathogenesis. In two transgenic models of …
Neutrophils in homeostasis, immunity, and cancer
Neutrophils were among the first leukocytes described and visualized by early
immunologists. Prominent effector functions during infection and sterile inflammation …
immunologists. Prominent effector functions during infection and sterile inflammation …
Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease
Introduction Neutrophil accumulation is a well-established feature of Alzheimer's disease
(AD) and has been linked to cognitive impairment by modulating disease-relevant …
(AD) and has been linked to cognitive impairment by modulating disease-relevant …