Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

The innate immune system in diabetic retinopathy

WW Pan, F Lin, PE Fort - Progress in retinal and eye research, 2021 - Elsevier
The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

Neonatal sepsis as a cause of retinopathy of prematurity: An etiological explanation

O Dammann, BK Stansfield - Progress in retinal and eye research, 2024 - Elsevier
Retinopathy of prematurity (ROP) is a complex neonatal disorder with multiple contributing
factors. In this paper we have mounted the evidence in support of the proposal that neonatal …

NOD-like receptors in the eye: uncovering its role in diabetic retinopathy

RR Lim, ME Wieser, RR Ganga, VA Barathi… - International Journal of …, 2020 - mdpi.com
Diabetic retinopathy (DR) is an ocular complication of diabetes mellitus (DM). International
Diabetic Federations (IDF) estimates up to 629 million people with DM by the year 2045 …

Inhibition of inflammatory cells delays retinal degeneration in experimental retinal vein occlusion in mice

J Jovanovic, X Liu, D Kokona, MS Zinkernagel… - Glia, 2020 - Wiley Online Library
The role of microglia in retinal inflammation is still ambiguous. Branch retinal vein occlusion
initiates an inflammatory response whereby resident microglia cells are activated. They …

[HTML][HTML] Microglia in Cultured Porcine Retina: Qualitative Immunohistochemical Analyses of Reactive Microglia in the Outer Retina

K Johansson, C Mohlin - International Journal of Molecular Sciences, 2023 - mdpi.com
A late stage of several retinal disorders is retinal detachment, a complication that results in
rapid photoreceptor degeneration and synaptic damages. Experimental retinal detachment …

LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p

Y Wang, Y Wang, X Wang, Y Ma, Z Li, Y Di - Frontiers in Medicine, 2022 - frontiersin.org
Purpose Retinopathy of prematurity (ROP) is a common retinal vascular disease in
premature neonates. In recent years, there is increasing evidence that the long non-coding …

A modified protocol for isolation of retinal microglia from the pig

Y Zhang, AL Erhard, T Plagemann, N Eter… - Experimental Eye …, 2021 - Elsevier
Microglia are the resident immune cells in the retina. To investigate their properties and
behaviour, a reliable and yielding procedure to culture them is necessary. We here describe …

Isolation and Characterization of Primary Retinal Microglia From the Human Post-mortem Eyes for Future Studies of Ocular Diseases

L Wang, Y Qian, X Che, J Jiang, J Suo… - Frontiers in Cellular …, 2022 - frontiersin.org
Microglia, the primary resident immunocytes in the retina, continuously function as immune
system supervisors in sustaining intraocular homeostasis. Microglia relate to many diseases …

Retinal microglia-derived S100A9 incite NLRP3 inflammasome in a Western diet fed Ossabaw pig retina

RR Lim, AE Thomas, A Ramasubramanian… - bioRxiv, 2024 - biorxiv.org
Purpose: We established S100A9 as a myeloid-derived damage-associated molecular
pattern (DAMPs) protein associated with increasing severity of diabetic retinopathy (DR) in …