Cilia are hair-like projections found on almost all cells in the human body. Originally
believed to function merely in motility, the function of solitary non-motile (primary) cilia was …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the
primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent …

Primary cilia are microtubule based sensory organelles important for receiving and
processing cellular signals. Recent studies have shown that cilia also release extracellular …

In view of the prevalence of sensorineural hearing defects in an ageing population, the
development of protocols to generate cochlear hair cells and their associated sensory …

Bardet–Biedl syndrome (BBS) is a genetically heterogeneous, pleiotropic disorder,
characterized by both congenital and late onset defects. From the analysis of the mutational …

Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as
signaling molecules and environmental cues. These sensory organelles are crucial to the …

Intraflagellar transport (IFT) is a conserved mechanism believed to be essential for the
assembly and maintenance of cilia and flagella. However, little is known about its role in …

Stereocilia are actin-based protrusions on auditory and vestibular sensory cells that are
required for hearing and balance. They convert physical force from sound, head movement …

Vision impairment places a serious burden on the aging society, affecting the lives of
millions of people. Many retinal diseases are of genetic origin, of which over 50% are due to …