CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to
mosquito control. While attempts have been made to develop such systems in Aedes …

Mosquito transgenesis and gene-drive technologies provide the basis for developing
promising new tools for vector-borne disease prevention by either suppressing wild …

Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …

The yellow fever mosquito Aedes aegypti is a major vector of arthropod-borne viruses,
including dengue, chikungunya, and Zika viruses. A novel approach to mitigate arboviral …

Gene-edited mosquitoes lacking ag amma-i nterferon-inducible l ysosomal thiol reductase-
like protein, namely (mosGILT null) have lower Plasmodium infection, which is linked to …

The field-testing and eventual adoption of genetically-engineered mosquitoes (GEMs) to
control vector-borne pathogen transmission will require them meeting safety criteria …

Lipophorin is an essential, highly expressed lipid transport protein that is secreted and
circulates in insect hemolymph. We hijacked the Anopheles coluzzii Lipophorin gene to …

CRISPR/Cas9 technologies are important tools for the development of gene-drive systems
to modify mosquito vector populations to control the transmission of pathogens that cause …

Making discrete and precise genetic changes to wild populations has been proposed as a
means of addressing some of the world's most pressing ecological and public health …

Malaria remains a persistent global public health challenge because of the limitations of
current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria …