Scleral structure and biomechanics

C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen… - Progress in retinal and …, 2020 - Elsevier
As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy

RW Nickells, GR Howell, I Soto… - Annual review of …, 2012 - annualreviews.org
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …

Simultaneous assessment of the whole eye biomechanics using ultrasonic elastography

R Li, X Qian, C Gong, J Zhang, Y Liu… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Objective: Current elastography techniques in the field of ophthalmology usually target one
specific tissue, such as the cornea or the sclera. However, the eye is an inter-related organ …

[HTML][HTML] TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

Q Li, Y Cheng, S Zhang, X Sun, J Wu - Journal of neuroinflammation, 2021 - Springer
Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type of
retinal disease characterized by the selective death of retinal ganglion cells (RGCs) …

[HTML][HTML] Factors influencing optic nerve head biomechanics

IA Sigal, JG Flanagan, CR Ethier - … ophthalmology & visual …, 2005 - iovs.arvojournals.org
purpose. The biomechanical environment within the optic nerve head (ONH) may play a role
in retinal ganglion cell loss in glaucomatous optic neuropathy. This was a systematic …

Biomechanics of the optic nerve head

IA Sigal, CR Ethier - Experimental eye research, 2009 - Elsevier
Biomechanical factors acting at the level of the lamina cribrosa (LC) are postulated to play a
role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we …

[HTML][HTML] Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations

MJA Girard, JKF Suh, M Bottlang… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: To characterize scleral biomechanics in both eyes of eight monkeys in which
chronic intraocular pressure (IOP) elevation was induced in one eye. Methods.: Each …

Verification, validation and sensitivity studies in computational biomechanics

AE Anderson, BJ Ellis, JA Weiss - Computer methods in …, 2007 - Taylor & Francis
Computational techniques and software for the analysis of problems in mechanics have
naturally moved from their origins in the traditional engineering disciplines to the study of …

[HTML][HTML] Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients

AP Wells, DF Garway-Heath, A Poostchi… - … & visual science, 2008 - arvojournals.org
purpose. To investigate relationships between acute intraocular pressure (IOP)–induced
optic nerve head surface deformation and corneal hysteresis and thickness in glaucomatous …

Mechanical environment of the optic nerve head in glaucoma

JC Downs, MD Roberts… - Optometry and Vision …, 2008 - journals.lww.com
The optic nerve head (ONH) is of particular interest from a biomechanical perspective
because it is a weak spot within an otherwise strong corneo-scleral envelope. The lamina …