Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Polymers with precisely defined monomeric sequences present an exquisite tool for
controlling material properties by harnessing both the robustness of synthetic polymers and …

We have developed a method to detect DNA synthesis in proliferating cells, based on the
incorporation of 5-ethynyl-2′-deoxyuridine (EdU) and its subsequent detection by a …

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique
approach to medicinal chemistry based on physical organic chemical principles and …

Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

One of the initial steps in the development of therapeutic agents is the identification of lead
compounds that bind to the receptor or enzyme target of interest. Many analogs of these …

During the last six years, combinatorial chemistry has attracted enormous attention from the
pharmaceutical industry because it can greatly facilitate the drug discovery process. 1 At the …

We have synthesized and characterized a family of structured oligo-N-substituted-glycines
(peptoids) up to 36 residues in length by using an efficient solid-phase protocol to …

A series of homologous L‐amino acid, D‐amino acid, and both parallel and anti‐parallel
(retro) sequence N‐substituted glycine peptide and peptoid oligomers were prepared and …