Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Natural bioactive peptide discovery is a challenging and time-consuming process. However,
advances in synthetic biology are providing promising new avenues in peptide engineering …

Covering: up to 2018 Symbiotic microbes interact with animals, often by producing natural
products (specialized metabolites; secondary metabolites) that exert a biological role. A …

Cyanobactin biosynthetic enzymes have exceptional versatility in the synthesis of natural
and unnatural products. Cyanobactins are ribosomally synthesized and posttranslationally …

This review focuses on the prochlorosin and cyanobactin biosynthetic pathways, unusual
examples of pathways in cyanobacteria that appear to be diversity generating. In the case of …

Aromatic prenyltransferases from cyanobactin biosynthetic pathways catalyse the
chemoselective and regioselective intramolecular transfer of prenyl/geranyl groups from …

Cyclic peptides are ubiquitous drug candidates, placing macrocyclization reactions at the
apex of drug development. PatG and related dual-action proteases from cyanobactin …

Multiple backbone N‐methylation and macrocyclization improve the proteolytic stability and
oral availability of therapeutic peptides. Chemical synthesis of such peptides is challenging …

Patellamides are highly bioactive compounds found along with other cyanobactins in the
symbiosis between didemnid ascidians and the enigmatic cyanobacterium Prochloron. The …

Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that
the prenyl-D-Arg-containing autumnalamide A is a member of the cyanobactin family …