Isomerizations between cis and trans conformers in Xaa–Pro amide bonds (Xaa= any amino
acid, Pro= proline) are crucial in many natural processes such as protein folding and signal …

Acetates derived from the adducts of the Baylis− Hillman reaction can be reacted in a
regioselective manner with amines in the presence of palladium (0) catalyst to afford α …

Tertiary amides, which usually occur as cis/trans mixtures, can be effectively shifted to the cis
conformation by placing a positive charge in close proximity to the amide carbonyl. This …

A combination of the ferrocene scaffold as a central reverse-turn unit with the dipeptide
chains (-l-Pro-l-Ala-NHPy) was demonstrated to induce both inverse γ-turn-like and …

Background The advent of combinatorial chemistry has revived the interest in five-
membered heterocyclic rings as scaffolds in pharmaceutical research. They are also the …

GPR54 is a Gq‐protein coupled receptor involved in cancer metastasis and regulation of the
endocrine system. GPR54 activation by endogenous ligands attenuates the mobility of …

Peptide secondary structure mimetics should accurately imitate the desired backbone
conformation, and synthetic routes to peptidomimetics should allow for flexible introduction …

2-Oxopiperazine derivatives 1 have been designed as mimetics of γ-turn conformationally
constrained tripeptides. The synthetic pathway devised for the preparation of both epimers of …

The conformational study of a new group of synthetic peptides containing 4-amino-1, 2-
dithiolane-4-carboxylic acid (Adt), a cysteine-related achiral residue, has been carried out …

Short syntheses of enantiomeric templated scaffolds of cis-and trans-tetrahydrofuran γ-
amino acids from pentono-δ-lactones derived from arabinose and ribose are reported; an …