[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats

KE Poti, DJ Sullivan, AM Dondorp, CJ Woodrow - Trends in parasitology, 2020 - cell.com
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …

Genetic diversity and deletion of Plasmodium falciparum histidine-rich protein 2 and 3: a threat to diagnosis of P. falciparum malaria

M Gendrot, R Fawaz, J Dormoi, M Madamet… - Clinical Microbiology …, 2019 - Elsevier
Background PfHRP2-based rapid diagnostic tests (RDTs), based on the recognition of the
Plasmodium falciparum histidine-rich protein 2, are currently the most used tests in malaria …

[HTML][HTML] An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

A Ahouidi, M Ali, J Almagro-Garcia… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

[HTML][HTML] Major threat to malaria control programs by Plasmodium falciparum lacking histidine-rich protein 2, Eritrea

A Berhane, K Anderson, S Mihreteab… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
False-negative results for Plasmodium falciparum histidine-rich protein (HRP) 2–based
rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 …

Factors affecting the performance of HRP2-based malaria rapid diagnostic tests

X Martiáñez-Vendrell, M Skjefte, R Sikka… - Tropical Medicine and …, 2022 - mdpi.com
The recent COVID-19 pandemic has profoundly impacted global malaria elimination
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …

A world free of malaria: It is time for Africa to actively champion and take leadership of elimination and eradication strategies

CO Egwu, C Aloke, J Chukwu, A Agwu, E Alum… - African Health …, 2022 - ajol.info
The global burden of malaria seems unabated. Africa carries the greatest burden accounting
for over 95% of the annual cases of malaria. For the vision of a world free of malaria by …

High proportions of pfhrp2 gene deletion and performance of HRP2-based rapid diagnostic test in Plasmodium falciparum field isolates of Odisha

P Pati, G Dhangadamajhi, M Bal, M Ranjit - Malaria journal, 2018 - Springer
Background With the documentation of cases of falciparum malaria negative by rapid
diagnostic tests (RDT), though at low frequency from natural isolates in a small pocket of …

Plasmodium falciparum histidine-rich protein 2 and 3 genes deletion in global settings (2010–2021): a systematic review and meta-analysis

A Jejaw Zeleke, A Hailu, AG Bayih, M Kefale, AT Amare… - Malaria Journal, 2022 - Springer
Background The usefulness of histidine-rich protein-2/3 (HRP2/3)-based rapid diagnostic
tests of malaria due to Plasmodium falciparum has been threatened by the appearance of …

Impact of Plasmodium falciparum gene deletions on malaria rapid diagnostic test performance

ML Gatton, A Chaudhry, J Glenn, S Wilson, Y Ah… - Malaria Journal, 2020 - Springer
Background Malaria rapid diagnostic tests (RDTs) have greatly improved access to
diagnosis in endemic countries. Most RDTs detect Plasmodium falciparum histidine-rich …

Malaria rapid diagnostic tests: literary review and recommendation for a quality assurance, quality control algorithm

MJ Kavanaugh, SE Azzam, DM Rockabrand - Diagnostics, 2021 - mdpi.com
Malaria rapid diagnostic tests (RDTs) have had an enormous global impact which
contributed to the World Health Organization paradigm shift from empiric treatment to …