Syndromes of thrombotic microangiopathy

JN George, CM Nester - New England Journal of Medicine, 2014 - Mass Medical Soc
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Thrombotic thrombocytopenic purpura

BS Joly, P Coppo, A Veyradier - Blood, The Journal of the …, 2017 - ashpublications.org
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic
microangiopathy characterized by microangiopathic hemolytic anemia, severe …

In vitro microvessels for the study of angiogenesis and thrombosis

Y Zheng, J Chen, M Craven, NW Choi… - Proceedings of the …, 2012 - National Acad Sciences
Microvascular networks support metabolic activity and define microenvironmental conditions
within tissues in health and pathology. Recapitulation of functional microvascular structures …

Pathophysiology of thrombotic thrombocytopenic purpura

JE Sadler - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
The discovery of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif,
member 13 (ADAMTS13) revolutionized our approach to thrombotic thrombocytopenic …

[HTML][HTML] Endothelium—role in regulation of coagulation and inflammation

VWM van Hinsbergh - Seminars in immunopathology, 2012 - Springer
By its strategic position at the interface between blood and tissues, endothelial cells control
blood fluidity and continued tissue perfusion while simultaneously they direct inflammatory …

[HTML][HTML] von Willebrand factor and inflammation

C Kawecki, PJ Lenting, CV Denis - Journal of Thrombosis and Haemostasis, 2017 - Elsevier
Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic
role in serving as a molecular bridge linking platelets to subendothelial components …

The growing complexity of platelet aggregation

SP Jackson - Blood, The Journal of the American Society of …, 2007 - ashpublications.org
Platelet aggregation, the process by which platelets adhere to each other at sites of vascular
injury, has long been recognized as critical for hemostatic plug formation and thrombosis …

Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and …

JA Reese, DS Muthurajah, JAK Hovinga… - Pediatric blood & …, 2013 - Wiley Online Library
Background Thrombotic thrombocytopenic purpura (TTP) associated with severe, acquired
ADAMTS13 deficiency is uncommonly reported in children. The incidence, demographic …

Thrombotic thrombocytopenic purpura

JN George - New England Journal of Medicine, 2006 - Mass Medical Soc
A 40-year-old obese black woman has had weakness and epigastric pain for several weeks
and diarrhea and vomiting for four days. She does not appear acutely ill; the physical …

The vessel wall and its interactions

DD Wagner, PS Frenette - Blood, The Journal of the American …, 2008 - ashpublications.org
Blood cell interactions with the vessel wall were first documented almost 170 years ago.
Modern advances have revealed that leukocyte and platelet interactions with the …