Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Oxidized phospholipids as a unifying theory for lipoprotein (a) and cardiovascular disease

MB Boffa, ML Koschinsky - Nature Reviews Cardiology, 2019 - nature.com
Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

Lipoprotein (a), PCSK9 inhibition, and cardiovascular risk: insights from the FOURIER trial

ML O'Donoghue, S Fazio, RP Giugliano, ESG Stroes… - Circulation, 2019 - Am Heart Assoc
Background: Lipoprotein (a)[Lp (a)] may play a causal role in atherosclerosis. PCSK9
(proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce …

Lipoprotein (a): Knowns, unknowns and uncertainties

M Ruscica, CR Sirtori, A Corsini, GF Watts… - Pharmacological …, 2021 - Elsevier
Over the last 10 years, there have been advances on several aspects of lipoprotein (a)
which are reviewed in the present article. Since the standard immunoassays for measuring …

Familial hypercholesterolemia and elevated lipoprotein (a): double heritable risk and new therapeutic opportunities

A Vuorio, GF Watts, WJ Schneider… - Journal of internal …, 2020 - Wiley Online Library
There is compelling evidence that the elevated plasma lipoprotein (a)[Lp (a)] levels increase
the risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. Like …

Persistent arterial wall inflammation in patients with elevated lipoprotein (a) despite strong low-density lipoprotein cholesterol reduction by proprotein convertase …

LCA Stiekema, ESG Stroes, SL Verweij… - European heart …, 2019 - academic.oup.com
Aims Subjects with lipoprotein (a)[Lp (a)] elevation have increased arterial wall inflammation
and cardiovascular risk. In patients at increased cardiovascular risk, arterial wall …

Recent advances in demystifying the metabolism of lipoprotein (a)

K Chemello, DC Chan, G Lambert, GF Watts - Atherosclerosis, 2022 - Elsevier
Abstract Lipoprotein (a)(Lp (a)) is a strange lipoprotein species causatively independently
and significantly associated with cardiovascular diseases and calcified aortic valve stenosis …

Lipoprotein (a) catabolism: a case of multiple receptors

SPA McCormick, WJ Schneider - Pathology, 2019 - Elsevier
Summary Lipoprotein (a)[Lp (a)] is an apolipoprotein B (apoB)-containing plasma lipoprotein
similar in structure to low-density lipoprotein (LDL). Lp (a) is more complex than LDL due to …

A new dawn for managing dyslipidemias: The era of rna-based therapies

C Macchi, CR Sirtori, A Corsini, RD Santos… - Pharmacological …, 2019 - Elsevier
The high occurrence of atherosclerotic cardiovascular disease (ASCVD) events is still a
major public health issue. Although a major determinant of ASCVD event reduction is the …

[HTML][HTML] The PCSK9 revolution: current status, controversies, and future directions

BA Warden, S Fazio, MD Shapiro - Trends in cardiovascular medicine, 2020 - Elsevier
Abstract Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) has revolutionized our
understanding of cholesterol homeostasis and added to our arsenal against atherosclerotic …