During induction of trained immunity, monocytes and macrophages undergo a functional
and transcriptional reprogramming toward increased activation. Important rewiring of cellular …

The experimental infectivity and excellent tolerance of some rodent autonomous
parvoviruses in humans, together with their oncosuppressive effects in preclinical models …

The current study aims to investigate the antidiabetic efficacy of camel milk-derived
lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling …

Microbes were hypothesized to play a key role in the progression of type 1 diabetes (T1D).
We used the LEW1. WR1 rat model of Kilham rat virus (KRV)-induced T1D to test the …

The gastrointestinal system represents one of the largest interfaces between the human
internal microenvironment and the external world. This system harbors trillions of …

We recently hypothesized that the intestinal microbiota and the innate immune system play
key roles in the mechanism of Kilham Rat Virus-induced type 1 diabetes in the LEW1. WR1 …

In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8+ T
cells, together with a significant number of other inflammatory cells, including CD8+ T …

The digestive tract hosts trillions of bacteria that interact with the immune system and can
influence the balance between pro-inflammatory and regulatory immune responses. Recent …

Background Comprehensive understanding of molecular mechanisms underlying viral
infection is a major challenge towards the discovery of new antiviral drugs and susceptibility …

Context: Recent studies have implicated proinflammatory responses in the mechanism of
type 1 diabetes (T1D). Objective: Our objective was to evaluate the safety and effects of …