Antibiotics are among the most successful drugs used for human therapy. However, since
they can challenge microbial populations, they must be considered as important pollutants …

The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …

Over the past decade, a growing community of researchers has emerged around the use of
constraint-based reconstruction and analysis (COBRA) methods to simulate, analyze and …

Small colony variants constitute a slow-growing subpopulation of bacteria with distinctive
phenotypic and pathogenic traits. Phenotypically, small colony variants have a slow growth …

Staphylococcus aureus is a preeminent bacterial pathogen capable of colonizing diverse
ecological niches within its human host. We describe here the pangenome of S. aureus …

Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

The human gut microbiome plays an influential role in maintaining human health and it is a
potential target for prevention and treatment of disease. Genome-scale metabolic models …

Background Photosynthetic organisms convert atmospheric carbon dioxide into numerous
metabolites along the pathways to make new biomass. Aquatic photosynthetic organisms …

It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …

Antibiotic resistance is one of the few examples of evolution that can be addressed
experimentally. The present review analyses this resistance, focusing on the networks that …