Nuclear compartmentalization as a mechanism of quantitative control of gene expression
Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
[PDF][PDF] RNA promotes the formation of spatial compartments in the nucleus
RNA, DNA, and protein molecules are highly organized within three-dimensional (3D)
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a
transcription initiation complex, and a transition to an elongation complex,,–. The large …
transcription initiation complex, and a transition to an elongation complex,,–. The large …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
Nuclear speckles: molecular organization, biological function and role in disease
L Galganski, MO Urbanek… - Nucleic acids …, 2017 - academic.oup.com
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
known as nuclear domains or nuclear subcompartments. These self-organizing structures …
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
Phase separation of RNA-binding protein promotes polymerase binding and transcription
An RNA-involved phase-separation model has been proposed for transcription control.
However, the molecular links that connect RNA to the transcription machinery remain …
However, the molecular links that connect RNA to the transcription machinery remain …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
[HTML][HTML] Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing
Transcription is a highly dynamic process. Consequently, we have developed native
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …