This review summarises the role that reactive oxygen and nitrogen species play in
demyelination, such as that occurring in the inflammatory demyelinating disorders multiple …

Nitric oxide (NO) is a gaseous molecule that plays many key roles in the cardiovascular
system. Each of the enzymes that generate NO—neuronal, inducible and endothelial NO …

NITRIC oxide (NO), a potent vasodilator produced by endothelial cells, is thought to be the
endothelium-dependent relaxing factor (EDRF) which mediates vascular relaxation in …

Background The major source of superoxide (· O2−) in vascular tissues is an NADH/NADPH-
dependent, membrane-bound oxidase. We have previously shown that this oxidase is …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Francis A. Bainbridge demonstrated in 1915 that an infusion of saline or blood into the
jugular vein of the anesthetized dog produced tachycardia. His findings after transection of …

Endothelial production of nitric oxide is critical to the regulation of vascular responses,
including vascular tone and regional blood flow, leukocyte–endothelial interactions, platelet …

Alteration in function of the cardiac autonomic nervous system has proved to be a powerful
predictor of cardiac death or serious arrhythmia in patients with cardiac disease, yet little is …

The discovery in 1990 that nitric oxide (NO) acts as a neuromodulator within the central and
peripheral nervous system triggered intensive research which considerably extended our …

Baroreceptors sense and signal the central nervous system of changes in arterial pressure
through a series of sensory processes. An increase in arterial pressure causes vascular …