[HTML][HTML] Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models to disease mechanisms
S Guo - The Journal of endocrinology, 2014 - ncbi.nlm.nih.gov
Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
S Du, H Zheng - Cell & bioscience, 2021 - Springer
Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …
of life-saving medicines, our life expectancy has increased substantially across the world in …
Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids
RA Haeusler, B Astiarraga, S Camastra, D Accili… - Diabetes, 2013 - Am Diabetes Assoc
Bile acids (BAs) exert pleiotropic metabolic effects, and physicochemical properties of
different BAs affect their function. In rodents, insulin regulates BA composition, in part by …
different BAs affect their function. In rodents, insulin regulates BA composition, in part by …
FOXO transcription factors: their clinical significance and regulation
Y Wang, Y Zhou, DT Graves - BioMed research international, 2014 - Wiley Online Library
Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
[HTML][HTML] Selective inhibition of FOXO1 activator/repressor balance modulates hepatic glucose handling
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
Z Sun, RA Miller, RT Patel, J Chen, R Dhir, H Wang… - Nature medicine, 2012 - nature.com
Fatty liver disease is associated with obesity and type 2 diabetes, and hepatic lipid
accumulation may contribute to insulin resistance. Histone deacetylase 3 (Hdac3) controls …
accumulation may contribute to insulin resistance. Histone deacetylase 3 (Hdac3) controls …
[HTML][HTML] SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed
countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here …
countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here …
[HTML][HTML] The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits
MC Costanzo, M von Grotthuss, J Massung, D Jang… - Cell metabolism, 2023 - cell.com
Associations between human genetic variation and clinical phenotypes have become a
foundation of biomedical research. Most repositories of these data seek to be disease …
foundation of biomedical research. Most repositories of these data seek to be disease …
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …
FoxO1, the transcriptional chief of staff of energy metabolism
S Kousteni - Bone, 2012 - Elsevier
FoxO1, one of the four FoxO isoforms of Forkhead transcription factors, is highly expressed
in insulin-responsive tissues, including pancreas, liver, skeletal muscle and adipose tissue …
in insulin-responsive tissues, including pancreas, liver, skeletal muscle and adipose tissue …