[HTML][HTML] Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models to disease mechanisms

S Guo - The Journal of endocrinology, 2014 - ncbi.nlm.nih.gov
Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …

Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

S Du, H Zheng - Cell & bioscience, 2021 - Springer
Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids

RA Haeusler, B Astiarraga, S Camastra, D Accili… - Diabetes, 2013 - Am Diabetes Assoc
Bile acids (BAs) exert pleiotropic metabolic effects, and physicochemical properties of
different BAs affect their function. In rodents, insulin regulates BA composition, in part by …

FOXO transcription factors: their clinical significance and regulation

Y Wang, Y Zhou, DT Graves - BioMed research international, 2014 - Wiley Online Library
Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …

[HTML][HTML] Selective inhibition of FOXO1 activator/repressor balance modulates hepatic glucose handling

F Langlet, RA Haeusler, D Lindén, E Ericson, T Norris… - Cell, 2017 - cell.com
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Z Sun, RA Miller, RT Patel, J Chen, R Dhir, H Wang… - Nature medicine, 2012 - nature.com
Fatty liver disease is associated with obesity and type 2 diabetes, and hepatic lipid
accumulation may contribute to insulin resistance. Histone deacetylase 3 (Hdac3) controls …

[HTML][HTML] SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

J Shin, M He, Y Liu, S Paredes, L Villanova, K Brown… - Cell reports, 2013 - cell.com
Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed
countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here …

[HTML][HTML] The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits

MC Costanzo, M von Grotthuss, J Massung, D Jang… - Cell metabolism, 2023 - cell.com
Associations between human genetic variation and clinical phenotypes have become a
foundation of biomedical research. Most repositories of these data seek to be disease …

Role of Forkhead Box O (FOXO) transcription factor in aging and diseases

N Tia, AK Singh, P Pandey, CS Azad, P Chaudhary… - Gene, 2018 - Elsevier
Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …

FoxO1, the transcriptional chief of staff of energy metabolism

S Kousteni - Bone, 2012 - Elsevier
FoxO1, one of the four FoxO isoforms of Forkhead transcription factors, is highly expressed
in insulin-responsive tissues, including pancreas, liver, skeletal muscle and adipose tissue …