Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Importance Ubrogepant is an oral calcitonin gene–related peptide receptor antagonist under
investigation for acute treatment of migraine. Objective To evaluate the efficacy and …

Migraine is the most prevalent neurological disorder worldwide and it has immense
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …

The quality of clinical trials is an essential part of the evidence base for the treatment of
headache disorders. In 1991, the International Headache Society Clinical Trials Standing …

Migraine is a highly disabling neurovascular disorder characterized by a severe headache
(associated with nausea, photophobia and/or phonophobia), and trigeminovascular system …

Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

This review discusses the most common forms of temporomandibular disorders: myofascial
pain disorder, intra-articular disk derangement disorders, osteoarthritis, and rheumatoid …