The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for
the past decade. Profound advances in human stem cell biology and technology, tissue …

The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …

Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is …

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) provide a promising
source for cell therapy and drug screening. Several high-yield protocols exist for hESC-CM …

Rationale: RBPs (RNA-binding proteins) have been described to be expressed and
regulated in various organs including the heart. Little is known about the role of RBPs in …

Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …

Skin is the outermost covering of the human body and at the same time the largest organ
comprising 15% of body weight and 2 m2 surface area. Skin plays a key role as a barrier …

The breakthrough of reprogramming human somatic cells was achieved in 2006 by the work
of Yamanaka and Takahashi. From this point, fibroblasts are the most commonly used …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system
represent two instruments of basic and translational research, which both allow to acquire …