Antibiofilm activity of host defence peptides: complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

Recent advances in understanding enteric pathogenic Escherichia coli

MA Croxen, RJ Law, R Scholz… - Clinical microbiology …, 2013 - Am Soc Microbiol
Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

[HTML][HTML] The human cathelicidin LL-37—A pore-forming antibacterial peptide and host-cell modulator

D Xhindoli, S Pacor, M Benincasa, M Scocchi… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies

F Alcayaga-Miranda, J Cuenca, M Khoury - Frontiers in immunology, 2017 - frontiersin.org
While mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are
concerns regarding possible side effects related to the unwanted suppression of …

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

D Vandamme, B Landuyt, W Luyten, L Schoofs - Cellular immunology, 2012 - Elsevier
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic …

Molecular mechanisms of Escherichia coli pathogenicity

MA Croxen, BB Finlay - Nature Reviews Microbiology, 2010 - nature.com
Escherichia coli is a remarkable and diverse organism. This normally harmless commensal
needs only to acquire a combination of mobile genetic elements to become a highly adapted …

The vitamin D–antimicrobial peptide pathway and its role in protection against infection

AF Gombart - Future microbiology, 2009 - Taylor & Francis
Vitamin D deficiency has been correlated with increased rates of infection. Since the early
19th century, both environmental (ie, sunlight) and dietary sources (cod liver) of vitamin D …

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

Vitamin d-directed rheostatic regulation of monocyte antibacterial responses

JS Adams, S Ren, PT Liu, RF Chun… - The Journal of …, 2009 - journals.aai.org
The active form of vitamin D, 1, 25-dihydroxyvitamin D (1, 25 (OH) 2 D) enhances innate
immunity by inducing the cathelicidin antimicrobial peptide (hCAP). In monocytes …

Biosynthesis, bioactivity, biotoxicity and applications of antimicrobial peptides for human health

D Wei, X Zhang - Biosafety and Health, 2022 - mednexus.org
Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their broad-
spectrum resistance to bacteria, fungi, viruses and parasites, and influencing the host …