Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

Aims Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic
cells (DCs)] in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell …

Technology at the single‐cell level has advanced dramatically in characterizing molecular
heterogeneity. These technologies have enabled cell subtype diversity to be seen in all …

Cholesterol-overloaded cells or “foam cells” in the artery wall are the biochemical hallmark
of atherosclerosis, and are responsible for much of the growth, inflammation and …

BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs)
disease, including brain bleedings and thrombosis that cause neurological disabilities in …

Purpose Despite an increase in treatment options, and substantial reductions in
cardiovascular mortality over the past half-century, atherosclerosis remains the most …

The endothelium, the monolayer of endothelial cells that line blood vessels, is exposed to a
number of mechanical forces, including frictional shear flow, pulsatile stretching and …

An incomplete understanding of the cellular functions and underlying mechanisms of zinc
ions released from zinc‐based stents in atherosclerosis (AS) therapy is one of the major …

Macrophages are strategically located throughout the body at key sites in the immune
system. A key feature in atherosclerosis is the uptake and accumulation of lipoproteins by …