Atg8-family proteins—structural features and molecular interactions in autophagy and beyond
Autophagy is a common name for a number of catabolic processes, which keep the cellular
homeostasis by removing damaged and dysfunctional intracellular components. Impairment …
homeostasis by removing damaged and dysfunctional intracellular components. Impairment …
Advances toward precision medicine for bipolar disorder: mechanisms & molecules
Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …
the effective treatment, and prevention of bipolar disorder represents an area of significant …
Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: a genome-wide association study and meta-analysis
HJ Li, C Zhang, L Hui, DS Zhou, Y Li, CY Zhang… - JAMA …, 2021 - jamanetwork.com
Importance The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully
understood. Objective To explore the genetic basis of BD in the Han Chinese population …
understood. Objective To explore the genetic basis of BD in the Han Chinese population …
The amyloid precursor protein modulates the position and length of the axon initial segment
The amyloid precursor protein (APP) is linked to the genetics and pathogenesis of
Alzheimer's disease (AD). It is the parent protein of the β-amyloid (Aβ) peptide, the main …
Alzheimer's disease (AD). It is the parent protein of the β-amyloid (Aβ) peptide, the main …
Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings
Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
Roles of palmitoylation in structural long-term synaptic plasticity
B Ji, M Skup - Molecular brain, 2021 - Springer
Long-term potentiation (LTP) and long-term depression (LTD) are important cellular
mechanisms underlying learning and memory processes. N-Methyl-d-aspartate receptor …
mechanisms underlying learning and memory processes. N-Methyl-d-aspartate receptor …
DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models
H Liu, RN Caballero-Florán, T Hergenreder… - PLoS …, 2023 - journals.plos.org
Down syndrome (DS) is caused by the trisomy of human chromosome 21 (HSA21). A major
challenge in DS research is to identify the HSA21 genes that cause specific symptoms …
challenge in DS research is to identify the HSA21 genes that cause specific symptoms …
Ankyrins and neurological disease
SR Stevens, MN Rasband - Current opinion in neurobiology, 2021 - Elsevier
Highlights•Ankyrins link membrane proteins to the cytoskeleton to form and maintain
membrane micro-domains.•Ankyrins cluster and organize protein complexes that modulate …
membrane micro-domains.•Ankyrins cluster and organize protein complexes that modulate …
Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites
AD Nelson, AM Catalfio, JP Gupta, L Min… - Neuron, 2024 - cell.com
Dysfunction in sodium channels and their ankyrin scaffolding partners have both been
implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In …
implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In …
Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder …
ANK3 is a leading bipolar disorder (BD) candidate gene in humans and provides a unique
opportunity for studying epilepsy-BD comorbidity. Previous studies showed that deletion of …
opportunity for studying epilepsy-BD comorbidity. Previous studies showed that deletion of …