Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

There is a growing body of literature demonstrating the importance of T cell exhaustion in
regulating and shaping immune responses to pathogens and cancer. Simultaneously, the …

Relapse has emerged as the most important cause of treatment failure after allogeneic
hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer …

Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …

NK cells have therapeutic potential for a wide variety of human malignancies. However,
because NK cells expand poorly in vitro, have limited life spans in viv o, and represent a …

Natural killer (NK) cells are attractive within adoptive transfer settings in cancer
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …

PD-1 expression is a hallmark of both early antigen-specific T cell activation and later
chronic stimulation, suggesting key roles in both naive T cell priming and memory T cell …

Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia …

Chimeric antigen receptor (CAR)-modified natural killer (NK) cells represent a promising
immunotherapeutic modality for cancer treatment. However, their potential utilities have not …