Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Introduction: Molecular dynamics (MD) simulations can provide not only plentiful dynamical
structural information on biomacromolecules but also a wealth of energetic information …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

In recent years, several important advances have been made in our understanding of the
pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and …

In the late 1990s, mutations in the synaptic protein α-synuclein (α-syn) were identified in
families with hereditary Parkinson's disease (PD). Rapidly, α-syn became the target of …

Aggregation of α‐synuclein (αS) is involved in the pathogenesis of Parkinson's disease (PD)
and a variety of related neurodegenerative disorders. The physiological function of αS is …

Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs
or domains that recognize the curvature, concave or convex, deep or shallow, of lipid …

Parkinson's disease is characterized by the presence of intracellular aggregates composed
primarily of the neuronal protein α-synuclein (αS). Interactions between αS and various …

The distinctive pathological hallmarks of Parkinson's disease are the progressive death of
dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α …

Alpha-synuclein (αS) is a 140-amino-acid protein that is involved in a number of
neurodegenerative diseases. In Parkinson's disease, the protein is typically encountered in …