Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells.
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …

Contents Summary 1197 I. Introduction 1198 II. Measurement and imaging of H2O2 1198 III.
H2O2 and O2·− toxicity 1199 IV. Production of H2O2: enzymes and subcellular locations …

Aged and degenerated intervertebral discs are characterised by a significant increase in the
number of senescent cells, which may be associated with the deterioration of this tissue due …

Genetically encoded probes based on the H2O2-sensing proteins OxyR and Orp1 have
greatly increased the ability to detect elevated H2O2 levels in stimulated or stressed cells …

Objective A decline in mitochondrial function and biogenesis as well as increased reactive
oxygen species (ROS) are important determinants of aging. With advancing age, there is a …

Biomimetic hydrogels have been developed in the fabrication of multifunctional
microenvironments for cell culture and tissue fabrication. In the current study, different …

Significance: The redox balance of cells provides a stable microenvironment for biological
macromolecules to perform their physiological functions. As redox imbalance is closely …

Reactive oxygen species were discovered in living organisms in the early 1950's and their
action has been implicated in diverse biological processes. First formulated by H. Sies in …