Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Hydroxyl radical protein footprinting (HRPF) coupled to mass spectrometry has been
successfully used to investigate a plethora of protein-related questions. The method, which …

To the Editor—For certain diseases, patients who have been previously infected by one
strain of a virus and who are later infected by another strain can suffer outcomes that are …

Hydrogen exchange coupled to mass spectrometry (MS) has become a valuable analytical
tool for the study of protein dynamics. By combining information about protein dynamics with …

▪ Abstract Mass spectrometry has provided a powerful method for monitoring hydrogen
exchange of protein backbone amides with deuterium from solvent. In comparison to …

Antibodies are of importance for the field of proteomics, both as reagents for imaging cells,
tissues, and organs and as capturing agents for affinity enrichment in mass-spectrometry …

Fast photochemical oxidation of proteins (FPOP) is a MS-based method that has proved
useful in studies of protein structures, interactions, conformations, and protein folding. The …

The increasing resistance of many microbial strains to antibiotics, delayed laboratory results,
and side effects of many chemotherapeutics has raised the need to search for sensitive …

Vaccine design is progressing from empiricism towards the increasingly rational
presentation of the targets of protective immunity. Nevertheless, most current vaccine …

Mass spectrometric epitope mapping has become a versatile method to precisely determine
a soluble antigen's partial structure that directly interacts with an antibody in solution. Typical …