Mechanisms of disease: inflammatory bowel diseases

GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

Why is initial bacterial colonization of the intestine important to infants' and children's health?

PD Houghteling, WA Walker - Journal of pediatric …, 2015 - journals.lww.com
Microbial colonization of the infant occurs during a critical time window for immune and
gastrointestinal development. Infant colonization sets the stage for the adult microbiome …

A clinical review of recent findings in the epidemiology of inflammatory bowel disease

A Ponder, MD Long - Clinical epidemiology, 2013 - Taylor & Francis
Inflammatory bowel diseases (IBD), including both Crohn's disease and ulcerative colitis,
are disorders of chronic inflammation of the gastrointestinal tract marked by episodes of …

The role of environmental factors in the pathogenesis of inflammatory bowel diseases: a review

DS Shouval, PA Rufo - JAMA pediatrics, 2017 - jamanetwork.com
Importance Inflammatory bowel diseases (IBD), such as Crohn disease and ulcerative
colitis, are chronic relapsing conditions that affect a growing number of children worldwide …

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

LJ Wammes, H Mpairwe, AM Elliott… - The Lancet Infectious …, 2014 - thelancet.com
Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in
affluent countries, the deliberate infection of patients with worms is being explored as a …

The role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review

JE Axelrad, KH Cadwell… - Therapeutic …, 2021 - journals.sagepub.com
The inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative
colitis (UC), are chronic, progressive, inflammatory conditions of the gastrointestinal tract …

Eosinophils and helminth infection: protective or pathogenic?

E Mitre, AD Klion - Seminars in immunopathology, 2021 - Springer
Since the earliest descriptions of this enigmatic cell, eosinophils have been implicated in
both protective and pathogenic immune responses to helminth infection. Nevertheless …

Helminths in the gastrointestinal tract as modulators of immunity and pathology

F Varyani, JO Fleming… - American Journal of …, 2017 - journals.physiology.org
Helminth parasites are highly prevalent in many low-and middle-income countries, in which
inflammatory bowel disease and other immunopathologies are less frequent than in the …

Inflammatory bowel disease in sub-Saharan Africa: epidemiology, risk factors, and challenges in diagnosis

G Watermeyer, L Katsidzira, M Setshedi… - The Lancet …, 2022 - thelancet.com
Over the past century, the incidence of inflammatory bowel disease (IBD) in high-income
countries has shown a sharp rise that then plateaued, and a similar trend has been …

The underrated gut microbiota helminths, bacteriophages, fungi, and archaea

MJ Garcia-Bonete, A Rajan, F Suriano, E Layunta - Life, 2023 - mdpi.com
The microbiota inhabits the gastrointestinal tract, providing essential capacities to the host.
The microbiota is a crucial factor in intestinal health and regulates intestinal physiology …