Patients with chronic granulomatous disease (CGD) suffer from recurrent, life-threatening
bacterial and fungal infections of the skin, the airways, the lymph nodes, liver, brain and …

A set of electrostatically charged, fluorescent, and superparamagnetic nanoprobes was
developed for targeting cancer cells without using any molecular biomarkers. The surface …

C ONVINCING evidence exists that blood transfusions are associated with deleterious
effects caused by residual leukocytes in blood and blood components. These side effects …

Neutrophil research relies largely on studies with highly purified cells. Yet the isolation
procedures induce changes in surface expression of several proteins. We used a large …

To develop a purification strategy for isolating the most primitive hematopoietic stem cells
present in normal human marrow we have combined cell separation techniques with an …

Leukocyte transendothelial migration (TEM) has been modeled as a multistep process
beginning with rolling adhesion, followed by firm adhesion, and ending with either …

Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency
disorder of phagocytes resulting in impaired killing of bacteria and fungi. A mutation in one …

Reactive oxygen species (ROS) control the integrity of the vascular endothelium. Our
laboratory has recently shown that transduction of human umbilical vein endothelial cells …

We have previously reported that neutrophilic granulocytes rapidly release part of their
FcγRIII from the plasma membrane upon in vitro activation, probably by proteolytic cleavage …

Abstract Leukocyte adhesion deficiency-1/variant (LAD1v) syndrome presents early in life
and manifests by infections without pus formation in the presence of a leukocytosis …