Fifteen years have passed since the cloning and characterization of the interleukin-1β-
converting enzyme (ICE/caspase-1), the first identified member of a family of proteases …

Inflammasomes are cytoplasmic multiprotein complexes that mediate the maturation of the
proinflammatory cytokines interleukin-1β (IL-1β), IL-18, and possibly IL-33 by controlling the …

Background Identification of single nucleotide polymorphisms (SNPs) for specific genes
involved in reproduction might improve reliability of genomic estimates for these low …

The last 10 years have witnessed the identification of a new class of intracellular pattern-
recognition molecules—the nucleotide-binding domain and leucine-rich repeat–containing …

Abstract Background NLRPs (Nucleotide-binding oligomerization domain, Leucine rich
Repeat and Pyrin domain containing Proteins) are members of NLR (Nod-like receptors) …

Maternal effect genes encode proteins that are produced during oogenesis and play an
essential role during early embryogenesis. Genetic ablation of such genes in oocytes can …

Heat shock proteins (HSP) regulate inflammation in many physiological contexts. However,
inflammation is a broad process, involving numerous cytokines produced by different …

Background The NLRP (Nucleotide-binding oligomerization domain, Leucine rich Repeat
and Pyrin domain containing) family, also referred to as NALP family, is well known for its …

Nucleotide‐binding oligomerization domain receptors (NOD‐like receptors, NLR s) are
intracellular proteins that are chiefly known for their critical functions in inflammatory …

Abstract Background Mater (Maternal Antigen that Embryos Require), also known as Nalp5
(NACHT, leucine rich repeat and PYD containing 5), is an oocyte-specific maternal effect …