The complexity of p53-mediated metabolic regulation in tumor suppression
Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …
and apoptosis are well accepted as critical barriers to cancer development, accumulating …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
The function and regulation of TET2 in innate immunity and inflammation
B Cong, Q Zhang, X Cao - Protein & cell, 2021 - academic.oup.com
TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …
Roles and regulations of TET enzymes in solid tumors
The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
Optophysiology: Illuminating cell physiology with optogenetics
Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …
and organisms with tailored functions. Optogenetics has the advantages of …
Triangular relationship between p53, autophagy, and chemotherapy resistance
J Xu, NH Patel, DA Gewirtz - International Journal of Molecular Sciences, 2020 - mdpi.com
Chemotherapy and radiation often induce a number of cellular responses, such as
apoptosis, autophagy, and senescence. One of the major regulators of these processes is …
apoptosis, autophagy, and senescence. One of the major regulators of these processes is …
Targeting epigenetic regulatory machinery to overcome cancer therapy resistance
Drug resistance, either intrinsic or acquired, represents a major hurdle to achieving optimal
therapeutic outcomes during cancer treatment. In addition to acquisition of resistance …
therapeutic outcomes during cancer treatment. In addition to acquisition of resistance …
Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication
Y Hu, X Chen, Y Ling, K Zhou, M Han, X Wang… - PLoS …, 2023 - journals.plos.org
Influenza A virus (IAV) expresses several accessory proteins to limit host anti-viral restriction
factors to facilitate viral replication. The Ten-Eleven Translocation 2 (TET2) is a …
factors to facilitate viral replication. The Ten-Eleven Translocation 2 (TET2) is a …
Oxygen regulation of TET enzymes
Hypoxia has a significant impact on many physiological and pathological processes. Over
the recent years, its role in modulation of epigenetic remodelling has also become clearer. In …
the recent years, its role in modulation of epigenetic remodelling has also become clearer. In …
Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas
Y Ye, N Ding, L Mi, Y Shi, W Liu, Y Song, S Shu… - … hematology & oncology, 2021 - Springer
Objective To explore the correlation of mutation landscape with clinical outcomes in patients
with peripheral T-cell lymphoma (PTCL). Methods We retrospectively analyzed the …
with peripheral T-cell lymphoma (PTCL). Methods We retrospectively analyzed the …