[HTML][HTML] CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer

B Wang, M Wang, D Ao, X Wei - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Chemokine CXC motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays
an important role in the immune system. The interaction between CXCL13 and its receptor …

CXCL13/CXCR5 signaling axis in cancer

M Hussain, D Adah, M Tariq, Y Lu, J Zhang, J Liu - Life sciences, 2019 - Elsevier
The tumor microenvironment comprises stromal and tumor cells which interact with each
other through complex cross-talks that are mediated by a variety of growth factors, cytokines …

Obesity and prostate cancer—microenvironmental roles of adipose tissue

A Saha, MG Kolonin, J DiGiovanni - Nature Reviews Urology, 2023 - nature.com
Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

[HTML][HTML] CXCL10 and CCL21 promote migration of pancreatic cancer cells toward sensory neurons and neural remodeling in tumors in mice, associated with pain in …

M Hirth, J Gandla, C Höper, MM Gaida, N Agarwal… - Gastroenterology, 2020 - Elsevier
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is frequently accompanied
by excruciating pain, which has been associated with attraction of cancer cells and their …

Potential role of CXCL13/CXCR5 signaling in immune checkpoint inhibitor treatment in cancer

CH Hsieh, CZ Jian, LI Lin, GS Low, PY Ou, C Hsu… - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy is currently the backbone of new drug treatments for many
cancer patients. CXC chemokine ligand 13 (CXCL13) is an important factor involved in …

CXCL13–CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis

S Biswas, S Sengupta, S Roy Chowdhury… - Breast cancer research …, 2014 - Springer
We investigated the expression of–CXC chemokine ligand 13 (CXCL13) and its receptor–
CXC chemokine receptor 5 (CXCR5) in 98 breast cancer (BC) patients with infiltrating duct …

CXCL13 in cancer and other diseases: biological functions, clinical significance, and therapeutic opportunities

SH Gao, SZ Liu, GZ Wang, GB Zhou - Life, 2021 - mdpi.com
The development of cancer is a multistep and complex process involving interactions
between tumor cells and the tumor microenvironment (TME). CXC chemokine ligand 13 …

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway

Z Zhu, X Zhang, H Guo, L Fu, G Pan, Y Sun - Molecular and cellular …, 2015 - Springer
CXCL13, an inflammatory factor in the microenvironment, plays a vital role in the
progression of inflammatory diseases and tumors. CXCL13 and its receptor CXCR5 have …

Causal associations of Sjögren's syndrome with cancers: a two-sample Mendelian randomization study

Y Jia, P Yao, J Li, X Wei, X Liu, H Wu, W Wang… - Arthritis Research & …, 2023 - Springer
Background Several observational studies have explored the associations between
Sjögren's syndrome (SS) and certain cancers. Nevertheless, the causal relationships remain …

CXC chemokine ligand‐13 promotes metastasis via CXCR5‐dependent signaling pathway in non‐small cell lung cancer

CC Chao, WF Lee, SW Wang, PC Chen… - Journal of Cellular …, 2021 - Wiley Online Library
The CXC chemokine ligand‐13 (CXCL13) is a chemoattractant of B cells and has been
implicated in the progression of many cancers. So far, CXCL13 and its related receptor …