Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers
R Roskoski Jr - Pharmacological research, 2019 - Elsevier
The EGFR family is among the most investigated receptor protein-tyrosine kinase groups
owing to its general role in signal transduction and in oncogenesis. This family consists of …
owing to its general role in signal transduction and in oncogenesis. This family consists of …
ErbB receptors and cancer
Z Wang - ErbB receptor signaling: methods and protocols, 2017 - Springer
The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …
The ErbB/HER family of protein-tyrosine kinases and cancer
R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
A historical overview of protein kinases and their targeted small molecule inhibitors
R Roskoski Jr - Pharmacological research, 2015 - Elsevier
Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and
they can modify the function of a protein in almost every conceivable way. Protein …
they can modify the function of a protein in almost every conceivable way. Protein …
Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …
on SRC function. However, a significant body of work has defined Src family kinases as key …
Trastuzumab mechanism of action; 20 years of research to unravel a dilemma
Simple Summary Overexpression of HER2 receptors have been identified in various types of
cancer including breast cancer and ovarian cancer. HER2 overexpression is generally …
cancer including breast cancer and ovarian cancer. HER2 overexpression is generally …
Treatment of HER2-positive breast cancer: current status and future perspectives
CL Arteaga, MX Sliwkowski, CK Osborne… - Nature reviews Clinical …, 2012 - nature.com
The advent of HER2-directed therapies has significantly improved the outlook for patients
with HER2-positive early stage breast cancer. However, a significant proportion of these …
with HER2-positive early stage breast cancer. However, a significant proportion of these …
Untangling the ErbB signalling network
Y Yarden, MX Sliwkowski - Nature reviews Molecular cell biology, 2001 - nature.com
When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger
a rich network of signalling pathways, culminating in responses ranging from cell division to …
a rich network of signalling pathways, culminating in responses ranging from cell division to …
Endocytosis and cancer
I Mellman, Y Yarden - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …
Prevalence, Clinicopathologic Associations, and Molecular Spectrum of ERBB2 (HER2) Tyrosine Kinase Mutations in Lung Adenocarcinomas
ME Arcila, JE Chaft, K Nafa, S Roy-Chowdhuri… - Clinical cancer …, 2012 - AACR
Purpose: Activating mutations in the tyrosine kinase domain of HER2 (ERBB2) have been
described in a subset of lung adenocarcinomas (ADCs) and are mutually exclusive with …
described in a subset of lung adenocarcinomas (ADCs) and are mutually exclusive with …