Oculocutaneous albinism (OCA) is an autosomal recessive syndromic and non-syndromic
defect with deficient or a complete lack of the melanin pigment. The characteristics of OCA …

Tyrosinase (TYR) plays a vital role in melanin biosynthesis and is widely regarded as a
relatively specific marker for melanocytic lesions which involve vitiligo, malignant cutaneous …

Background Oculocutaneous albinism (OCA) is a genetically heterogeneous condition that
is associated with reduced or absent melanin pigment in the skin, hair, and eyes, resulting in …

Tyrosinase (TYR) is an important polyphenolic oxidase enzyme and usually regards as a
biomarker of melanoma cancer. Highly effective tracking TYR activity in vivo will help to …

Background Oculocutaneous albinism type1 (OCA1) is caused by the TYR gene's
homozygous and compound heterozygous variants. TKFC gene variants cause triokinase & …

Melanoma is an aggressive malignant tumor that undergoes rapid growth and metastasis in
a short time; tyrosinase (TYR) is an important biomarker for melanoma diagnosis as it is over …

Waardenburg syndrome (WS) is a disorder of neural crest cell migration characterized by
auditory and pigmentary abnormalities. We investigated a cohort of 14 families (16 subjects) …

Oculocutaneous albinism (OCA) is an autosomal recessive disorder of abnormal melanin
biosynthesis characterized by hypopigmentation of skin, hair and eyes. The patients with …

Background Oculocutaneous albinism (OCA) is a genetically heterogeneous disorder of
abnormal melanin synthesis, resulting in decreased or absent pigmentation of eyes, skin …

Herein, a novel self-assembling ratiometric fluorescent micelle nanoprobe (NanoDPA-NMP-
tyr) based on Förster Resonance Energy Transfer (FRET) was developed and was used to …