Endogenous opiates and behavior: 2012
RJ Bodnar - Peptides, 2013 - Elsevier
This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …
concerning the endogenous opioid system. It summarizes papers published during 2012 …
Morphinan derivatives with an oxabicyclo [3.2. 1] octane structure as dual agonists toward δ and κ opioid receptors
Y Uenohara, S Tsumura, S Hirayama, E Higashi… - Bioorganic & Medicinal …, 2022 - Elsevier
The κ opioid receptor (KOR) is one of the promising targets to develop analgesics lacking
morphine like side effects. To seek a novel KOR agonist we designed 6-amide derivatives …
morphine like side effects. To seek a novel KOR agonist we designed 6-amide derivatives …
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain
R Nakajima, N Yamamoto, S Hirayama, T Iwai… - Bioorganic & Medicinal …, 2015 - Elsevier
We designed and synthesized pentacyclic propellane derivatives with a 6-amide side chain
to afford compounds with higher MOR/KOR ratio and lower sedative effects than nalfurafine …
to afford compounds with higher MOR/KOR ratio and lower sedative effects than nalfurafine …
A synthesis of novel dioxapropellanes from the knoevenagel adducts of acenaphthoquinone and 3-oxo-3-arylpropionitriles in aqueous methanol
I Yavari, A Khajeh-Khezri, S Bahemmat, MR Halvagar - Synlett, 2017 - thieme-connect.com
A highly chemoselective and regioselective method for the synthesis of dioxopropellanes
developed by reaction of the Knoevenagel adducts of acenaphthoquinone (and ninhydrin) …
developed by reaction of the Knoevenagel adducts of acenaphthoquinone (and ninhydrin) …
Synthesis of Oxa-aza-and Bis-oxathiaaza [3.3. 3] propellanes from Dicyanomethylene-1, 3-indanedione and 2, 5-Dithiobiureas
An efficient route for the synthesis of oxa-aza-and bis-oxathiaaza [3.3. 3] propellanes via
reactions of symmetrical and unsymmetrical N 1, N 2-disubstituted hydrazine-1, 2 …
reactions of symmetrical and unsymmetrical N 1, N 2-disubstituted hydrazine-1, 2 …
A synthesis of oxo-thioxo [3.3. 3] propellanes from dithiocarbamates and ninhydrin–malononitrile adduct
I Yavari, A Khajeh-Khezri - Molecular Diversity, 2017 - Springer
An efficient method for the synthesis of oxo-thioxo 3.3. 3 propellanes via reaction of
dithiocarbamates, generated from primary amines and carbon disulfide, with the …
dithiocarbamates, generated from primary amines and carbon disulfide, with the …
[PDF][PDF] Design and Synthesis of Opioid Receptor Type Selective Ligands with a Propellane Skeleton and Their Pharmacologies
中嶋龍 - 2016 - tsukuba.repo.nii.ac.jp
2.1 Design of κ receptor selective propellane derivatives with pentacyclic skeleton 6 2.2
Synthesis of propellane derivatives with pentacyclic skeleton 7 2.3 Binding affinities and …
Synthesis of propellane derivatives with pentacyclic skeleton 7 2.3 Binding affinities and …