The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …

In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle
based on new structural data of the virus and its proteins. Specifically, we focus on the …

The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious
threat to the global public health. The viral protease that processes viral polyproteins during …

Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …

Dengue is a mosquito-borne viral hemorrhagic disease that is a major threat to human
health in tropical and subtropical regions. Here we report crystal structures of a peptide …

Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins. These compounds have a low molecular weight, making them penetrate …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

Antiviral drug discovery is becoming increasingly important due to the global threat of viral
disease pandemics. Many members of the genus Flavivirus are significant human …

Several flaviviruses are important human pathogens, including dengue virus, a disease
against which neither a vaccine nor specific antiviral therapies currently exist. During …

Flaviviruses are a major cause of infectious disease in humans. Dengue virus causes an
estimated 50 million cases of febrile illness each year, including an increasing number of …