HECT E3 ligases: a tale with multiple facets
J Weber, S Polo, E Maspero - Frontiers in physiology, 2019 - frontiersin.org
Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …
[HTML][HTML] Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects
M Scheffner, S Kumar - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …
Molecular pathophysiology of congenital long QT syndrome
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …
the fundamental cellular electrical event in the heart. The concerted function of these …
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …
potential. Some of the K+ channels are primarily responsible for early repolarization …
Cardiac sodium channel Nav1. 5 and interacting proteins: physiology and pathophysiology
H Abriel - Journal of molecular and cellular cardiology, 2010 - Elsevier
The cardiac voltage-gated Na+ channel Nav1. 5 generates the cardiac Na+ current (INa).
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …
Regulation of ion channels by the serum‐and glucocorticoid‐inducible kinase SGK1
F Lang, E Shumilina - The FASEB Journal, 2013 - Wiley Online Library
The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …
genomically regulated by cell stress (including cell shrinkage) and several hormones …
NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins
P Goel, JA Manning, S Kumar - Gene, 2015 - Elsevier
Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
B Yang, S Kumar - Cell Death & Differentiation, 2010 - nature.com
The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …
Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies
SA Kanner, Z Shuja, P Choudhury, A Jain… - Nature …, 2020 - nature.com
Impaired protein stability or trafficking underlies diverse ion channelopathies and represents
an unexploited unifying principle for developing common treatments for otherwise dissimilar …
an unexploited unifying principle for developing common treatments for otherwise dissimilar …