HECT E3 ligases: a tale with multiple facets

J Weber, S Polo, E Maspero - Frontiers in physiology, 2019 - frontiersin.org
Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

[HTML][HTML] Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects

M Scheffner, S Kumar - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop

GI Fishman, SS Chugh, JP DiMarco, CM Albert… - Circulation, 2010 - Am Heart Assoc
Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …

Molecular pathophysiology of congenital long QT syndrome

MS Bohnen, G Peng, SH Robey… - Physiological …, 2017 - journals.physiology.org
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

N Schmitt, M Grunnet, SP Olesen - Physiological reviews, 2014 - journals.physiology.org
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Cardiac sodium channel Nav1. 5 and interacting proteins: physiology and pathophysiology

H Abriel - Journal of molecular and cellular cardiology, 2010 - Elsevier
The cardiac voltage-gated Na+ channel Nav1. 5 generates the cardiac Na+ current (INa).
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …

Regulation of ion channels by the serum‐and glucocorticoid‐inducible kinase SGK1

F Lang, E Shumilina - The FASEB Journal, 2013 - Wiley Online Library
The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins

P Goel, JA Manning, S Kumar - Gene, 2015 - Elsevier
Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

B Yang, S Kumar - Cell Death & Differentiation, 2010 - nature.com
The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …

Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies

SA Kanner, Z Shuja, P Choudhury, A Jain… - Nature …, 2020 - nature.com
Impaired protein stability or trafficking underlies diverse ion channelopathies and represents
an unexploited unifying principle for developing common treatments for otherwise dissimilar …