Multiplex profiling of developmental cis-regulatory elements with quantitative single-cell expression reporters
The inability to scalably and precisely measure the activity of developmental cis-regulatory
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …
Multiplex profiling of developmental enhancers with quantitative, single-cell expression reporters
The inability to scalably and precisely measure the activity of developmental enhancers in
multicellular systems is a bottleneck in genomics. Here, we develop a dual RNA cassette …
multicellular systems is a bottleneck in genomics. Here, we develop a dual RNA cassette …
Widespread Increase in Enhancer—Promoter Interactions during Developmental Enhancer Activation in Mammals
Remote enhancers are thought to interact with their target promoters via physical proximity,
yet the importance of this proximity for enhancer function remains unclear. Although some …
yet the importance of this proximity for enhancer function remains unclear. Although some …
Identification of ancestral gnathostome Gli3 enhancers with activity in mammals
Abnormal expression of the transcriptional regulator and hedgehog (Hh) signaling pathway
effector Gli3 is known to trigger congenital disease, most frequently affecting the central …
effector Gli3 is known to trigger congenital disease, most frequently affecting the central …
Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs
CA Ferguson, BA Firulli, M Zoia… - Developmental …, 2024 - Wiley Online Library
Background The bHLH transcription factor HAND2 plays important roles in the development
of the embryonic heart, face, limbs, and sympathetic and enteric nervous systems. To define …
of the embryonic heart, face, limbs, and sympathetic and enteric nervous systems. To define …
[HTML][HTML] Mapping cis-and trans-regulatory target genes of human-specific deletions
Deletion of functional sequence is predicted to represent a fundamental mechanism of
molecular evolution 1, 2. Comparative genetic studies of primates 2, 3 have identified …
molecular evolution 1, 2. Comparative genetic studies of primates 2, 3 have identified …
A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival
S Abassah-Oppong, M Zoia, BJ Mannion… - Nature …, 2024 - nature.com
Approximately a quarter of the human genome consists of gene deserts, large regions
devoid of genes often located adjacent to developmental genes and thought to contribute to …
devoid of genes often located adjacent to developmental genes and thought to contribute to …