Abstract Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven
risk assessment approach that integrates new approach methodologies (NAMs) to assure …

Despite rigorous preclinical testing, clinical attrition rates in drug development remain high
with drug-induced liver injury (DILI) remaining one of the most frequent causes of project …

New approach methodologies (NAMs) that efficiently provide information about chemical
hazard without using whole animals are needed to accelerate the pace of chemical risk …

While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

Polycyclic aromatic hydrocarbons (PAHs) may interact with multiple intracellular receptors
and related signaling pathways. We comprehensively evaluated the toxicity profiles of six …

Abstract In 2016, the European Commission launched the EU-ToxRisk research project to
develop and promote animal-free approaches in toxicology. The 36 partners of this …

Microphysiological systems are an emerging area of in vitro drug development, and their
independent evaluation is important for wide adoption and use. The primary goal of this …

Cell Painting is a high-throughput phenotypic profiling assay that uses fluorescent
cytochemistry to visualize a variety of organelles and high-content imaging to derive a large …

Adaptive stress response pathways play a key role in the switch between adaptation and
adversity, and are important in drug-induced liver injury. Previously, we have established an …

Next-generation sequencing (NGS) represents several powerful platforms that have
revolutionized RNA and DNA analysis. The parallel sequencing of millions of DNA …