Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
JSL Yu, W Cui - Development, 2016 - journals.biologists.com
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …
mammalian target of rapamycin (mTOR) constitute the core components of the …
A decade of transcription factor-mediated reprogramming to pluripotency
K Takahashi, S Yamanaka - Nature reviews Molecular cell biology, 2016 - nature.com
The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
AA Kolodziejczyk, JK Kim, JCH Tsang, T Ilicic… - Cell stem cell, 2015 - cell.com
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
[HTML][HTML] Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo
Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …
Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation
KM Dorighi, T Swigut, T Henriques, NV Bhanu… - Molecular cell, 2017 - cell.com
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell
resource, with potential for studying disease and use in regenerative medicine. However …
resource, with potential for studying disease and use in regenerative medicine. However …
Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery
Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …
many gateways for the research in therapeutics. iPSCs are the cells which are …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
L Qian, Y Huang, CI Spencer, A Foley, V Vedantham… - Nature, 2012 - nature.com
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell
types holds great promise for regenerative medicine. We reported previously that cardiac …
types holds great promise for regenerative medicine. We reported previously that cardiac …