The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself

I Dalle-Donne, R Rossi, A Milzani, P Di Simplicio… - Free Radical Biology …, 2001 - Elsevier
Actin is the major constituent of the cytoskeleton of almost all the eukaryotic cells. In vitro
experiments have indicated that oxidant-stressed nonmuscle mammalian cells undergo …

Calcium ions and oxidative cell injury

S Orrenius, MJ Burkitt, GEN Kass… - Annals of Neurology …, 1992 - Wiley Online Library
Exposure of mammalian cells to oxidative stress induced by oxidation‐reduction‐active
quinones and other prooxidants results in depletion of intracellular glutathione, followed by …

Comparative effects of cadmium, copper, paraquat and benzo [a] pyrene on the actin cytoskeleton and production of reactive oxygen species (ROS) in mussel …

A Gómez-Mendikute, MP Cajaraville - Toxicology in vitro, 2003 - Elsevier
The immune defence of mussels is comprised of cell-mediated and humoral mechanisms, in
which haemocytes or blood cells play a key role. Environmental pollutants such as metallic …

Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

RC Calizo, S Bhattacharya, JGC van Hasselt… - Nature …, 2019 - nature.com
Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI)
treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System …

The role of calcium in cell killing

P Nicotera, G Bellomo, S Orrenius - Chemical research in …, 1990 - ACS Publications
The involvement of Ca2+ in the regulation of a large number of physiological processes is
now well established. Along with this knowledge has come the understanding that Ca2+ can …

Cerebral vasospasm and free radicals

RL Macdonald, BK Weir - Free Radical Biology and Medicine, 1994 - Elsevier
The literature implicating free radical reactions in the genesis of cerebral vasospasm
following aneurysmal subarachnoid hemorrhage is reviewed. While this condition has …

Oxygen radicals production and actin filament disruption in bivalve haemocytes treated with benzo (a) pyrene

A Gómez-Mendikute, A Etxeberria, I Olabarrieta… - Marine Environmental …, 2002 - Elsevier
Haemocytes play an essential role in the internal defence of molluscs. It has been reported
that organic xenobiotics commonly found as pollutants in the marine environment impair …

Biotransformation and cytotoxicity of a brominated flame retardant, tetrabromobisphenol A, and its analogues in rat hepatocytes

Y Nakagawa, T Suzuki, H Ishii, A Ogata - Xenobiotica, 2007 - Taylor & Francis
The metabolism and cytotoxic effects of tetrabromobisphenol A (TBBPA), a phenolic flame
retardant, and its analogues were studied in freshly isolated rat hepatocytes and isolated …

Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction

Y Nakagawa, T Suzuki, H Ishii, D Nakae, A Ogata - Archives of toxicology, 2011 - Springer
The cytotoxic effects of hydroxylated fullerenes, also termed fullerenols or fullerols [C 60
(OH) n], which are known nanomaterials and water-soluble fullerene derivatives, were …

Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione

J Gilloteaux, JM Jamison, DR Neal… - Ultrastructural …, 2010 - Taylor & Francis
A human bladder carcinoma cell line RT4 was sham-treated with buffer or treated with
ascorbate (VC) alone, menadione alone (VK3), or a combination of ascorbate: menadione …